People are relying on AI agents to assist them with various tasks.

This report presents the winning solution for Task 2 of Colliding with Adversaries: A Challenge on Robust Learning in High Energy Physics Discovery at ECML-PKDD 2025. The goal of the challenge was to design and train a robust ANN-based model capable of achieving high accuracy in a binary classification task on both clean and adversarial data generated with the Random Distribution Shuffle Attack (RDSA). Our solution consists of two components: a data generation phase and a robust model training phase. In the first phase, we produced 15 million artificial training samples using a custom methodology derived from Random Distribution Shuffle Attack (RDSA). In the second phase, we introduced a robust architecture comprising (i)a Feature Embedding Block with shared weights among features of the same type and (ii)a Dense Fusion Tail responsible for the final prediction. Training this architecture on our adversarial dataset achieved a mixed accuracy score of 80\%, exceeding the second-place solution by two percentage points.

ML-Enabled Systems (MLES) are inherently complex since they require multiple components to achieve their business goal. This experience report showcases the software architecture reusability techniques applied while building Ocean Guard, an MLES for anomaly detection in the maritime domain. In particular, it highlights the challenges and lessons learned to reuse the Ports and Adapters pattern to support building multiple microservices from a single codebase. This experience report hopes to inspire software engineers, machine learning engineers, and data scientists to apply the Hexagonal Architecture pattern to build their MLES.

In pre-market drug safety review, grouping related adverse event terms into SMQs or OCMQs is critical for signal detection. We assess the performance of SafeTerm Automated Medical Query (AMQ) on MedDRA SMQs. The AMQ is a novel quantitative artificial intelligence system that understands and processes medical terminology and automatically retrieves relevant MedDRA Preferred Terms (PTs) for a given input query, ranking them by a relevance score (0-1) using multi-criteria statistical methods. The system (SafeTerm) embeds medical query terms and MedDRA PTs in a multidimensional vector space, then applies cosine similarity, and extreme-value clustering to generate a ranked list of PTs. Validation was conducted against tier-1 SMQs (110 queries, v28.1). Precision, recall and F1 were computed at multiple similarity-thresholds, defined either manually or using an automated method. High recall (94%)) is achieved at moderate similarity thresholds, indicative of good retrieval sensitivity. Higher thresholds filter out more terms, resulting in improved precision (up to 89%). The optimal threshold (0.70)) yielded an overall recall of (48%) and precision of (45%) across all 110 queries. Restricting to narrow-term PTs achieved slightly better performance at an increased (+0.05) similarity threshold, confirming increased relatedness of narrow versus broad terms. The automatic threshold (0.66) selection prioritizes recall (0.58) to precision (0.29). SafeTerm AMQ achieves comparable, satisfactory performance on SMQs and sanitized OCMQs. It is therefore a viable supplementary method for automated MedDRA query generation, balancing recall and precision. We recommend using suitable MedDRA PT terminology in query formulation and applying the automated threshold method to optimise recall. Increasing similarity scores allows refined, narrow terms selection.

Bug localization remains a critical yet time-consuming challenge in large-scale software repositories. Traditional information retrieval-based bug localization (IRBL) methods rely on unchanged bug descriptions, which often contain noisy information, leading to poor retrieval accuracy. Recent advances in large language models (LLMs) have improved bug localization through query reformulation, yet the effect on agent performance remains unexplored. In this study, we investigate how an LLM-powered agent can improve file-level bug localization via lightweight query reformulation and summarization. We first employ an open-source, non-fine-tuned LLM to extract key information from bug reports, such as identifiers and code snippets, and reformulate queries pre-retrieval. Our agent then orchestrates BM25 retrieval using these preprocessed queries, automating localization workflow at scale. Using the best-performing query reformulation technique, our agent achieves 35% better ranking in first-file retrieval than our BM25 baseline and up to +22% file retrieval performance over SWE-agent.

The PRO-CTCAE is an NCI-developed patient-reported outcome system for capturing symptomatic adverse events in oncology trials. It comprises a large library drawn from the CTCAE vocabulary, and item selection for a given trial is typically guided by expected toxicity profiles from prior data. Selecting too many PRO-CTCAE items can burden patients and reduce compliance, while too few may miss important safety signals. We present an automated method to select a minimal yet comprehensive PRO-CTCAE subset based on historical safety data. Each candidate PRO-CTCAE symptom term is first mapped to its corresponding MedDRA Preferred Terms (PTs), which are then encoded into Safeterm, a high-dimensional semantic space capturing clinical and contextual diversity in MedDRA terminology. We score each candidate PRO item for relevance to the historical list of adverse event PTs and combine relevance and incidence into a utility function. Spectral analysis is then applied to the combined utility and diversity matrix to identify an orthogonal set of medical concepts that balances relevance and diversity. Symptoms are rank-ordered by importance, and a cut-off is suggested based on the explained information. The tool is implemented as part of the Safeterm trial-safety app. We evaluate its performance using simulations and oncology case studies in which PRO-CTCAE was employed. This automated approach can streamline PRO-CTCAE design by leveraging MedDRA semantics and historical data, providing an objective and reproducible method to balance signal coverage against patient burden.

In pre-market drug safety review, grouping related adverse event terms into standardised MedDRA queries or the FDA Office of New Drugs Custom Medical Queries (OCMQs) is critical for signal detection. We present a novel quantitative artificial intelligence system that understands and processes medical terminology and automatically retrieves relevant MedDRA Preferred Terms (PTs) for a given input query, ranking them by a relevance score using multi-criteria statistical methods. The system (SafeTerm) embeds medical query terms and MedDRA PTs in a multidimensional vector space, then applies cosine similarity and extreme-value clustering to generate a ranked list of PTs. Validation was conducted against the FDA OCMQ v3.0 (104 queries), restricted to valid MedDRA PTs. Precision, recall and F1 were computed across similarity-thresholds. High recall (>95%) is achieved at moderate thresholds. Higher thresholds improve precision (up to 86%). The optimal threshold (~0.70 - 0.75) yielded recall ~50% and precision ~33%. Narrow-term PT subsets performed similarly but required slightly higher similarity thresholds. The SafeTerm AI-driven system provides a viable supplementary method for automated MedDRA query generation. A similarity threshold of ~0.60 is recommended initially, with increased thresholds for refined term selection.

In this thesis, we developed a comprehensive framework for sentiment analysis that takes its many aspects into account mainly for Turkish. We have also proposed several approaches specific to sentiment analysis in English only. We have accordingly made five major and three minor contributions. We generated a novel and effective feature set by combining unsupervised, semi-supervised, and supervised metrics. We then fed them as input into classical machine learning methods, and outperformed neural network models for datasets of different genres in both Turkish and English. We created a polarity lexicon with a semi-supervised domain-specific method, which has been the first approach applied for corpora in Turkish. We performed a fine morphological analysis for the sentiment classification task in Turkish by determining the polarities of morphemes. This can be adapted to other morphologically-rich or agglutinative languages as well. We have built a novel neural network architecture, which combines recurrent and recursive neural network models for English. We built novel word embeddings that exploit sentiment, syntactic, semantic, and lexical characteristics for both Turkish and English. We also redefined context windows as subclauses in modelling word representations in English. This can also be applied to other linguistic fields and natural language processing tasks. We have achieved state-of-the-art and significant results for all these original approaches. Our minor contributions include methods related to aspect-based sentiment in Turkish, parameter redefinition in the semi-supervised approach, and aspect term extraction techniques for English. This thesis can be considered the most detailed and comprehensive study made on sentiment analysis in Turkish as of July, 2020. Our work has also contributed to the opinion classification problem in English.

Neural methods for Complex Query Answering (CQA) over knowledge graphs (KGs) are widely believed to learn patterns that generalize beyond explicit graph structure, allowing them to infer answers that are unreachable through symbolic query processing. In this work, we critically examine this assumption through a systematic analysis comparing neural CQA models with an alternative, training-free query relaxation strategy that retrieves possible answers by relaxing query constraints and counting resulting paths. Across multiple datasets and query structures, we find several cases where neural and relaxation-based approaches perform similarly, with no neural model consistently outperforming the latter. Moreover, a similarity analysis reveals that their retrieved answers exhibit little overlap, and that combining their outputs consistently improves performance. These results call for a re-evaluation of progress in neural query answering: despite their complexity, current models fail to subsume the reasoning patterns captured by query relaxation. Our findings highlight the importance of stronger non-neural baselines and suggest that future neural approaches could benefit from incorporating principles of query relaxation.